TARGETING THE ACHILLES' HEEL
OF CANCER INVASION AND METASTASIS

CREATING A PANACEA
FOR CANCER METASTASIS

FIRST-IN-CLASS
INVADOPODIA-TARGETED
CANCER GENE-THERAPY

DRAMATIC TUMOR SHRINKAGE
WITHOUT CHEMOTHERAPY

OVERVIEW

Metastasis and recurrence are the primary causes of cancer mortality. Despite recent advances in molecularly targeted and immuno-oncology therapy, treating or preventing cancer recurrence and/or metastasis remains a hugely unmet clinical need. Most anti-cancer therapies are designed to shrink primary tumors but cannot prevent metastases. Invadopodia (a.k.a. “cellular feet”) are the driving force of invasion, growth, and metastasis of cancer cells in the three-dimensional microenvironments in vivo. Antapodia Therapeutics pioneers the identification of a series of "Master Invadopodial Regulator (MIRs)", which are exclusively expressed by invasive cancer cells and thereby can serve as ideal and safe therapeutic targets. The company develops breakthrough and first-in-class invadopodia-targeted siRNA gene therapy and antibody therapeutics, which provides an excitingly new avenue to treating aggressive and metastatic cancers.

LNP siRNA GENE THERAPY

Many human solid tumors, such as liver, breast, lung, and pancreatic cancers, are characterized by a highly dense fibrotic stroma termed “desmoplasia”, which impedes the penetration of therapeutics. Nanoparticle formulation is a clinically proven strategy to facilitate drug penetration in desmoplastic cancers, such as liposomal doxorubicin in breast cancer and liposomal irinotecan in pancreatic cancer. Lipid nanoparticle (LNP)-formulated small interfering RNA (siRNA) and gene editing have recently emerged as clinically proven strategies of the precision targeting of disease driver genes. Antapodia Therapeutics partners with industrial leaders to combine best-in-class next-generation LNPs and a novel "liver-blocking" technology to deliver invadopodia-targeted siRNA to hepatic, non-hepatic and/or metastatic cancers, providing an exciting new aveue for treating aggressive human cancers.

SEE HOW OUR ANTI-INVADOPODIA THERAPY WORKS 

Shown are patient-derived organoids derived from a triple-negative breast tumor with protruding invadopodia before (left) and after (right) treatment with anti-invadopodia LNP-siRNA AP-01. Invadopodia (MIR-01, green), cytosol (tubulin, red), nuclei (DAPI, blue). 

Product

AP-01 LNP-siRNA

(HCC, TNBC)

Target Gene

MIR-01

 

PoM/PoC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

Product

AP-03 mAb

(NSCLC, CRPC)

Target Gene

MIR-03

 

PoOM/PoC studies > In vitro testing > In vivo testing > Toxicity > IND enabling

MIR: Master Invadopodial Regulator; LNP: lipid nanoparticle; siRNA: small interfering RNA; MIR: Master Invadopodial Regulator; HCC: hepatocellular carcinoma; TNBC: triple-negative breast cancer; NSCLC: non-small cell lung cancer; CRPC: castration-resistant prostate cancer; mAb: monoclonal antibody.

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Designed by Justin V. Tsai in 2021

Copyright © Antapodia Therapeutics, Inc., WA, USA. All Rights Reserved.

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